This Knowledge Product seeks to underline and stress the added value of using a gender lens in the design and implementation of activities in agricultural supply chains, and reflects on current trends in gender mainstreaming, opportunities to accelerate action, and critical lessons-learned from initiatives that have already been implemented. Even though the need to minimize adverse social and environmental effects from supply chain activities is globally recognized, gender equality is still inconsistently prioritized, gender compliance challenging and consensus on its meaning, still elusive. Presenting a clear business case for gender equality and women’s empowerment in agricultural supply chains, this product will prove a useful guidance on gender mainstreaming to stakeholders involved in commodity-related projects.